Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

Irisin (Ir), a recently identified adipomyokine, cleaved and secreted to the circulation from the FNDC5 protein in response to physical activity and some environmental conditions has been postulated to induces the differentiation of a subset of white adipocytes into brown fat and mediates the beneficial effects of exercise on metabolic homeostasis. Polycystic ovary syndrome (PCOS) – one of the most frequent endocrinopathies affecting women of child-bearing age is associat...

Brown adipose tissue metabolism is of remarkable pathophysiological interest, because it could be a target for future therapies for obesity and metabolic syndrome. Irisin (Ir), recently identified novel adipomyokine is essential in a white-to-brown fatty tissue transdifferentiation, and mediates some of the positive influences on metabolic disorders through increase of energy expenditure. The exact regulation of Ir secretion and action is unknown but significant positive assoc...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has a wide variety of nonspecific symptoms from other organs that may mimic other diseases and delay the diagnosis. Nowadays PHPT evolves to less-symptomatic.Aim: The aim is to revise symptomatology profile of PHPT in a single region of Poland; and to help early PHPT diagnosis – encouraging interdisciplinary contact between me...

Introduction: Mutations in FSHβ gene leading to isolated follicle-stimulating hormone (FSH) deficiency are very rare and the disorder is inherited in an autosomal recessive manner. Up to date, only few case reports have been described in the literature.Case report: 25-years old woman was admitted to the Endocrinology Department with a suspicion of FSH deficiency. She was firstly diagnosed with primary amenorrhoea and impaired pubertal development at...

Some individuals with normal weight but probably visceral fat excess, called Metabolically Obese Normal-Weight (MONW), have disturbances typical for metabolic syndrome. We analyzed relationships between body fat distribution (estimated by DXA) and insulin resistance, serum inflammatory markers levels (CRP, IL-6, IL-18) and polymorphisms of IL-6 promoter and PPARγ in healthy, non-obese Polish subjects: 232 women (age 31.4±5.5; BMI 21.5±2.5) and 199 men (age 30.3&...

Objectives: Graves' disease (GD) is an autoimmune disease caused by combination of environmental and genetic factors. The CTLA-4 gene is a candidate gene for conferring susceptibility to thyroid autoimmunity. Increased serum level of soluble isoform of CTLA-4 molecule (sCTLA-4), resulting by alternative splicing, was found in some autoimmune diseases. The role of this molecule in the pathomechanism of autoimmunity has not been defined.The principa...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...

Background: Sclerostin is a protein secreted by osteocytes, that inhibits Wnt/ βcatenin signaling and was suggested to play a role in glucocorticoid-induced osteoporosis in mice. In humans data are inconsistent. Patients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.Aim: The aim of the study was to evaluate sclerostin concentrations, densitomet...

Objectives: SARS-Cov2 infection can lead to severe cytokine storm especially in obese patients. It is known that the cytokine storm might lead to severe clinical manifestations or even acute mortality in critically ill patients with COVID-19. Ghrelin as well as leptin can act as the proinflammatory cytokines. The essential question is whether the cytokine storm in COVID-19 patients with obesity is associated with adipokines dysregulation.Aim: The st...